Ronald C Wek Selected Research

Guanabenz (BR 750)

1/2019	Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation.
11/2015	Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.

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Ronald C Wek Research Topics

Disease

16	Starvation 01/2021 - 01/2002
6	Neoplasms (Cancer) 12/2019 - 04/2005
5	Cysts 01/2021 - 06/2004
5	Inflammation (Inflammations) 01/2019 - 11/2013
4	Infections 01/2020 - 04/2013
3	Body Weight (Weight, Body) 01/2022 - 08/2004
3	Obesity 01/2022 - 04/2010
3	Osteoporosis 01/2022 - 01/2017
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2019 - 10/2006
2	Toxoplasmosis 01/2019 - 11/2015
2	Non-alcoholic Fatty Liver Disease 01/2017 - 06/2015
2	Liver Diseases (Liver Disease) 01/2017 - 02/2015
2	Wolcott-Rallison syndrome 07/2004 - 08/2003
1	Type 2 Diabetes Mellitus (MODY) 01/2022
1	Weight Gain 01/2022
1	Atrophy 01/2022
1	Insulin Resistance 01/2022
1	Fatty Liver 01/2021
1	Neuroinflammatory Diseases 01/2019
1	Buruli Ulcer 01/2018
1	Neglected Diseases 01/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2016
1	Pancreatitis 01/2016
1	Malaria 11/2015
1	Tuberous Sclerosis (Bourneville's Disease) 05/2013
1	Leiomyoma (Uterine Fibroids) 05/2013
1	Malnutrition (Nutritional Deficiencies) 09/2009
1	Carcinogenesis 04/2008
1	Neoplasm Metastasis (Metastasis) 04/2008
1	Virus Diseases (Viral Diseases) 04/2008
1	Vesicular Stomatitis 04/2008
1	Genomic Instability 02/2007
1	Temporal Lobe Epilepsy 07/2006
1	Status Epilepticus (Complex Partial Status Epilepticus) 07/2006

Drug/Important Bio-Agent (IBA)

15	Amino Acids FDA Link 01/2021 - 01/2002
12	Phosphotransferases (Kinase)IBA 01/2021 - 08/2003
9	Asparaginase (Elspar)FDA Link 12/2019 - 10/2006
8	Eukaryotic Initiation Factor-2 (EIF 2)IBA 01/2019 - 02/2004
5	Proteins (Proteins, Gene)FDA Link 01/2014 - 01/2002
4	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 05/2013
4	Pharmaceutical PreparationsIBA 01/2019 - 08/2008
3	Transcription Factors (Transcription Factor)IBA 01/2022 - 05/2013
3	Peptide Initiation Factors (Initiation Factor)IBA 01/2021 - 05/2004
3	Antiparasitic Agents (Antiparasitics)IBA 01/2019 - 04/2013
3	Protein Kinases (Protein Kinase)IBA 11/2010 - 05/2004
2	Nuclear Matrix-Associated ProteinsIBA 01/2022 - 01/2019
2	Insulin (Novolin)FDA Link 01/2022 - 07/2004
2	EnzymesIBA 12/2019 - 05/2004
2	Guanabenz (BR 750)FDA Link 01/2019 - 11/2015
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 11/2013
2	Genetic Markers (Genetic Marker)IBA 01/2016 - 11/2013
2	Transfer RNA (tRNA)IBA 01/2014 - 05/2004
2	TOR Serine-Threonine KinasesIBA 11/2013 - 05/2013
2	Proteasome InhibitorsIBA 05/2013 - 04/2008
2	Histidine (L-Histidine)FDA Link 11/2010 - 08/2008
2	Sirolimus (Rapamycin)FDA Link 05/2010 - 11/2009
2	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2008 - 04/2005
2	Cationic Amino Acid Transporter 1IBA 02/2007 - 01/2002
2	arginyllysineIBA 02/2007 - 01/2002
2	Leucine (L-Leucine)FDA Link 08/2005 - 08/2004
1	Activating Transcription Factor 4IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	FilaminsIBA 01/2020
1	AsparagineIBA 12/2019
1	ExotoxinsIBA 01/2018
1	Virulence Factors (Pathogenicity Factors)IBA 01/2018
1	mycolactoneIBA 01/2018
1	Parathyroid Hormone (Parathormone)IBA 01/2017
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2017
1	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 01/2017
1	ApolipoproteinsIBA 01/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	CholesterolIBA 01/2017
1	Gemcitabine FDA Link 11/2016
1	Pancreatitis-Associated ProteinsIBA 01/2016
1	SirtuinsIBA 01/2016
1	Sirtuin 1IBA 01/2016
1	Nonesterified Fatty Acids (NEFA)IBA 06/2015
1	Interleukin-8 (Interleukin 8)IBA 06/2015
1	Transcription Factor CHOPIBA 06/2015
1	LipidsIBA 02/2015
1	Phosphates (Orthophosphate)IBA 02/2015
1	Antithrombin IIIIBA 02/2015
1	Glutamine (L-Glutamine)FDA Link 02/2014
1	Triglycerides (Triacylglycerol)IBA 11/2013
1	Glutathione PeroxidaseIBA 11/2013
1	trans-sodium crocetinate (crocetin)IBA 05/2013
1	Bortezomib (Velcade)FDA Link 05/2013
1	ribosomal protein L11IBA 05/2012
1	AntioxidantsIBA 11/2010
1	Cysteine (L-Cysteine)FDA Link 11/2010
1	Activating Transcription Factor 1IBA 08/2008
1	src-Family KinasesIBA 04/2008
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 04/2008
1	Prokaryotic Initiation Factor-2IBA 07/2006
1	Pilocarpine (Ocusert)FDA LinkGeneric 07/2006
1	UbiquitinIBA 04/2005

Therapy/Procedure

7	Therapeutics 01/2022 - 04/2005
1	Fat-Restricted Diet (Diet, Fat Restricted) 01/2022
1	Drug Therapy (Chemotherapy) 04/2005